Literature collection of the CovAmInf workgroup.
Editors Joshua T. Berryman Abdul Mannan Baig Artemi Bendandi Daniel Bonhenry Mattheos A.G. Koffas
Dasom Kong, Ki Hoon Park, Da-Hyun Kim, Nam Gyo Kim, Seung-Eun Lee, Nari Shin, Myung Geun Kook, Young Bong Kim, Kyung-Sun Kang
PubMed: 36697403 DOI: 10.1038/s41420-022-01288-8
SARS-CoV-2 infection in a brain organoid model resulted in microgliosis and the formation of beta amyloid plaques. An increase in phosphorylated tau (degradation resistant) was observed as well.
"assembloids": separately grow, and then fuse, vascular and cortical organoids. Result is a brain organoid that can illustrate cerebrovascular and BBB pathologies.