Theory of spike initiation, sensory systems, autonomous behavior, epistemology
Editor Romain Brette
Skander Mensi, Olivier Hagens, Wulfram Gerstner, Christian Pozzorini
PubMed: 26907675 DOI: 10.1371/journal.pcbi.1004761
I had to love this paper, because the authors basically experimentally confirm every theoretical prediction we had made in our paper on spike threshold adaptation (Platkiewicz and Brette, 2011). Essentially, what we had done is derive the dynamics of spike threshold from the dynamics of Nav channel inactivation. There were a number of non-trivial predictions, such as the shortening of the effective integration time constant, sensitivity to input variance, the specific way in which spike threshold depends on membrane potential, and the interaction between spike-triggered and subthreshold adaptation (that we touched upon in the discussion). This study uses a non-parametric model-fitting approach in cortical slices to empirically derive the dynamics of spike threshold (indirectly, based on responses to fluctuating currents), and the results are completely in line with our theoretical predictions.