This is similar to the blind in vivo automatic patch-clamp technique of Kodandaramaiah et al. (2016), with a few differences. One is that it is written in Matlab, also proprietary software. The more interesting difference, in my view, is the pressure controller. Instead of using 4 manually filled tanks, there is an automatic electronic system that adjusts the pressure to any specified value. It essentially mixes two pressure sources (+10 psi and -10 psi) using a PID controller programmed on an Arduino. The code is also freely available.