Literature Review in Immunology
In this peeriodical, I comment on recent articles in the realm of Immunology. Take-home message and Importance are included for a clear and concise literature review
Editors Nicolas Tremblay Maude Boisvert
T cell cytolytic capacity is independent of initial stimulation strength (2018)
Arianne C. Richard, Aaron T. L. Lun, Winnie W. Y. Lau, Berthold Göttgens, John C. Marioni, Gillian M. Griffiths
http://www.ncbi.nlm.nih.gov/pubmed/30013148
Aug 02, 2018 - Take-home Message:Does ligand potency dictate the signalling that is initiated to activate a CD8+ T cells? In this paper, Richard et al. shows, using a myriad of cutting-edge techniques, that ligand potency plays a role for the kinetics of activation (more potency = less time to si...
Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors (2018)
Thomas Duhen, Rebekka Duhen, Ryan Montler, Jake Moses, Tarsem Moudgil, Noel F. de Miranda, Cheri P. Goodall, Tiffany C. Blair, Bernard A. Fox, Jason E. McDermott, Shu-Ching Chang, Gary Grunkemeier, Rom Leidner, Richard Bryan Bell, Andrew D. Weinberg
http://www.ncbi.nlm.nih.gov/pubmed/30006565
Aug 02, 2018 - Take home message In this article, Duhen et al. identifies a new subset of CD8+ cells that are recruited and maintained within the tumor micro-environment. Using flow-cytometry and microarrays, they show that these tumor-infiltrating CD8 T cells have an exhaustion signature and ha...
CD4 T Cell Affinity Diversity Is Equally Maintained during Acute and Chronic Infection (2018)
Rakieb Andargachew, Ryan J. Martinez, Elizabeth M. Kolawole, Brian D. Evavold
http://www.ncbi.nlm.nih.gov/pubmed/29777029
Jul 31, 2018 - Does CD4+ affinity towards an antigen is a correlate of protection against infection? Take-home message In this article, Andargachew et al. postulate that it is not that simple of a question by showing that affinity diversity is maintained during both acute and chronic LCMV mouse i...
IFNγ: signalling, epigenetics and roles in immunity, metabolism, disease and cancer immunotherapy (2018)
Lionel B. Ivashkiv
http://www.ncbi.nlm.nih.gov/pubmed/29921905
Jul 31, 2018 - Good overview of the myriad of function of a classical cytokine that binds all immunologist-alike together: IFNγ Take home message quote adapted from text ''Advancement of our knowledge of IFNγ functions and mechanisms of action can be harnessed to develop new therapeutic strategi...
TH9 cells tackle advanced tumours (2018)
Alexandra Flemming
http://dx.doi.org/10.1038/s41577-018-0032-4
Jul 31, 2018 - Th9 CD4+ T cells is emerging as an important cellular subset to control and eradicate cancer via the activation of a large subsets of immune cell via IL-9 and IL-21. I will update when I can get access to the article.
Mechanisms of NAFLD development and therapeutic strategies (2018)
Scott L. Friedman, Brent A. Neuschwander-Tetri, Mary Rinella, Arun J. Sanyal
http://www.ncbi.nlm.nih.gov/pubmed/29967350
Jul 31, 2018 - Excellent review article on Non-Alcoholic Fatty Liver Disease (NAFLD). Take-home message (quote from article): ''success in discovering effective therapies for NASH will continue to rely upon fundamental biomedical investigation that links the microbiome, liver metabolism and respo...
Cutting-Edge Infectious Disease Diagnostics with CRISPR (2018)
Charles Chiu
http://dx.doi.org/10.1016/j.chom.2018.05.016
Jul 30, 2018 - Nice article by Chiu et al. that shows the potential application of CRISPR-Cas-Based Technology in the clinic. Take-home message Guide RNA molecules are constructed to target specific pathogens or tumor cells. After collection of clinical samples in a point-of-care setting, the CAS...
