A collection of the latest research illuminating structure, function or systems data for small GTPases of the RAS subfamily.
Editor Matthew J. Smith
Teresa T. Bonello, Kia Z. Perez-Vale, Kaelyn D. Sumigray, Mark Peifer
http://dx.doi.org/10.1242/dev.157941
Jun 05, 2018
RASSF1A uncouples Wnt from Hippo signalling and promotes YAP mediated differentiation via p73 (2018)
Angelos Papaspyropoulos, Leanne Bradley, Asmita Thapa, Chuen Yan Leung, Konstantinos Toskas, Delia Koennig, Dafni-Eleftheria Pefani, Cinzia Raso, Claudia Grou, Garth Hamilton, Nikola Vlahov, Anna Grawenda, Syed Haider, Jagat Chauhan, Ludovico Buti, Alexander Kanapin, Xin Lu, Francesca Buffa, Grigory Dianov, Alex von Kriegsheim, David Matallanas, Anastasia Samsonova, Magdalena Zernicka-Goetz, Eric O'Neill
http://www.ncbi.nlm.nih.gov/pubmed/29382819
Jun 05, 2018
Inhibition of Ras activity coordinates cell fusion with cell–cell contact during yeast mating (2018)
Laura Merlini, Bita Khalili, Omaya Dudin, Laetitia Michon, Vincent Vincenzetti, Sophie G. Martin
http://www.ncbi.nlm.nih.gov/pubmed/29453312
Jun 05, 2018
Differential Effector Engagement by Oncogenic KRAS (2018)
Tina L. Yuan, Arnaud Amzallag, Rachel Bagni, Ming Yi, Shervin Afghani, William Burgan, Nicole Fer, Leslie A. Strathern, Katie Powell, Brian Smith, Andrew M. Waters, David Drubin, Ty Thomson, Rosy Liao, Patricia Greninger, Giovanna T. Stein, Ellen Murchie, Eliane Cortez, Regina K. Egan, Lauren Procter, Matthew Bess, Kwong Tai Cheng, Chih-Shia Lee, Liam Changwoo Lee, Christof Fellmann, Robert Stephens, Ji Luo, Scott W. Lowe, Cyril H. Benes, Frank McCormick
http://dx.doi.org/10.1016/j.celrep.2018.01.051
Jun 05, 2018
Teklab Gebregiworgis, Christopher B. Marshall, Tadateru Nishikawa, Nikolina Radulovich, María-José Sandí, Zhenhao Fang, Robert Rottapel, Ming-Sound Tsao, Mitsuhiko Ikura
http://www.ncbi.nlm.nih.gov/pubmed/29543440
Jun 05, 2018
Molecular recognition of RAS/RAF complex at the membrane: Role of RAF cysteine-rich domain (2018)
Timothy Travers, Cesar A. López, Que N. Van, Chris Neale, Marco Tonelli, Andrew G. Stephen, S. Gnanakaran
http://dx.doi.org/10.1038/s41598-018-26832-4
Jun 05, 2018
KRAS Dimerization Impacts MEK Inhibitor Sensitivity and Oncogenic Activity of Mutant KRAS (2018)
Chiara Ambrogio, Jens Köhler, Zhi-Wei Zhou, Haiyun Wang, Raymond Paranal, Jiaqi Li, Marzia Capelletti, Cristina Caffarra, Shuai Li, Qi Lv, Sudershan Gondi, John C. Hunter, Jia Lu, Roberto Chiarle, David Santamaría, Kenneth D. Westover, Pasi A. Jänne
http://dx.doi.org/10.1016/j.cell.2017.12.020
Jun 05, 2018
A small molecule inhibitor of Rheb selectively targets mTORC1 signaling (2018)
Sarah J. Mahoney, Sridhar Narayan, Lisa Molz, Lauren A. Berstler, Seong A. Kang, George P. Vlasuk, Eddine Saiah
http://dx.doi.org/10.1038/s41467-018-03035-z
Jun 05, 2018
Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes (2018)
Sebastian Mueller, Thomas Engleitner, Roman Maresch, Magdalena Zukowska, Sebastian Lange, Thorsten Kaltenbacher, Björn Konukiewitz, Rupert Öllinger, Maximilian Zwiebel, Alex Strong, Hsi-Yu Yen, Ruby Banerjee, Sandra Louzada, Beiyuan Fu, Barbara Seidler, Juliana Götzfried, Kathleen Schuck, Zonera Hassan, Andreas Arbeiter, Nina Schönhuber, Sabine Klein, Christian Veltkamp, Mathias Friedrich, Lena Rad, Maxim Barenboim, Christoph Ziegenhain, Julia Hess, Oliver M. Dovey, Stefan Eser, Swati Parekh, Fernando Constantino-Casas, Jorge de la Rosa, Marta I. Sierra, Mario Fraga, Julia Mayerle, Günter Klöppel, Juan Cadiñanos, Pentao Liu, George Vassiliou, Wilko Weichert, Katja Steiger, Wolfgang Enard, Roland M. Schmid, Fengtang Yang, Kristian Unger, Günter Schneider, Ignacio Varela, Allan Bradley, Dieter Saur, Roland Rad
http://www.ncbi.nlm.nih.gov/pubmed/29364867
Jun 05, 2018
RASSF1A Deficiency Enhances RAS-Driven Lung Tumorigenesis (2018)
M. Lee Schmidt, Katharine R. Hobbing, Howard Donninger, Geoffrey J. Clark
http://dx.doi.org/10.1158/0008-5472.can-17-2466
Jun 05, 2018
K-Ras4B Remains Monomeric on Membranes over a Wide Range of Surface Densities and Lipid Compositions (2018)
Jean K. Chung, Young Kwang Lee, John-Paul Denson, William K. Gillette, Steven Alvarez, Andrew G. Stephen, Jay T. Groves
http://www.ncbi.nlm.nih.gov/pubmed/29320680
Jun 05, 2018
Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase (2018)
Dietrich A. Ruess, Guus J. Heynen, Katrin J. Ciecielski, Jiaoyu Ai, Alexandra Berninger, Derya Kabacaoglu, Kivanc Görgülü, Zahra Dantes, Sonja M. Wörmann, Kalliope N. Diakopoulos, Angeliki F. Karpathaki, Marlena Kowalska, Ezgi Kaya-Aksoy, Liang Song, Eveline A. Zeeuw van der Laan, María P. López-Alberca, Marc Nazaré, Maximilian Reichert, Dieter Saur, Mert M. Erkan, Ulrich T. Hopt, Bruno Sainz, Walter Birchmeier, Roland M. Schmid, Marina Lesina, Hana Algül
http://www.ncbi.nlm.nih.gov/pubmed/29808009
Jun 05, 2018