Focusing on the causal mechanisms that may underlie statistical associations reported elsewhere in the literature
Editor Jinkinson Smith
The Coherence Problem: Finding Meaning in GWAS Complexity (2019)
Mark A. Reimers, Carl Craver, Mikhail Dozmorov, Silviu-Alin Bacanu, Kenneth S. Kendler
http://dx.doi.org/10.1007/s10519-018-9935-x
Nov 27, 2018 - An interesting paper approaching genome-wide association studies from a simultaneously optimistic and pessimistic perspective. The abstract states, "Although many recent findings from well powered GWAS have been replicated in independent data sets, the genes identified have pi...
Nicole Koschate-Fischer, Wayne D. Hoyer, Nicola E. Stokburger-Sauer, Jan Engling
http://dx.doi.org/10.1007/s11747-017-0548-3
Nov 05, 2018 - This study looks at the mechanism by which life events affect purchasing behaviors. The results were mixed: "...experiencing a life event leads to an increase in consumer innovativeness that, in turn, decreases SOW [share of wallet]/SOU [share of units] for the preferred brand...
Rui Wang, Laura Fratiglioni, Grégoria Kalpouzos, Martin Lövdén, Erika J. Laukka, Lena Bronge, Lars-Olof Wahlund, Lars Bäckman, Chengxuan Qiu
http://dx.doi.org/10.1016/j.jalz.2016.06.2363
Sep 26, 2018 - Another good example: looking at the potential mechanism underlying the link between "cardiovascular risk burden and cognitive decline in old age" (assuming it's cause-and-effect with the first causing the second, of course).
Marco A. Caldieraro, Paolo Cassano
2 comments on PubPeer • http://www.ncbi.nlm.nih.gov/pubmed/30248638
Sep 26, 2018 - This was the first English-language result (and second overall result) when I searched PubMed for "mechanisms of action". Interesting quote from abstract: "The main proposed mechanism for PBM [photobiomodulation, apparently some sort of laser therapy] is the enhance...