In this peeriodical, I comment on recent articles in the realm of Immunology. Take-home message and Importance are included for a clear and concise literature review
Editors Nicolas Tremblay Maude Boisvert
Mechanisms of NAFLD development and therapeutic strategies (2018)
Scott L. Friedman, Brent A. Neuschwander-Tetri, Mary Rinella, Arun J. Sanyal
PubMed: 29967350 DOI: 10.1038/s41591-018-0104-9
Excellent review article on Non-Alcoholic Fatty Liver Disease (NAFLD).
Take-home message (quote from article): ''success in discovering effective therapies for NASH will continue to rely upon fundamental biomedical investigation that links the microbiome, liver metabolism and response to injury, systemic consequences of obesity and metabolic syndrome.''
Review includes: -Diagnostic criteria -Clinical disease progression -Risk factors for NAFLD and NASH -Pathogenesis -Preclinical models of NAFLD and NASH (in vitro and in vivo) -Treatment targets & clinical trials -Future prospects